About Mutalyzer

Contact

The Mutalyzer mailing list is a general discussion list for Mutalyzer. Messages can be posted to this list via the Google Groups interface or by sending an email to mutalyzer@googlegroups.com.

Bugs and concrete feature requests may also be filed directly in the GitHub issue tracker.

If you are a regular user of the Mutalyzer webservices or are maintaining your own Mutalyzer installation, consider subscribing to the Mutalyzer Announcements mailing list. This is a low-volume mailing list for announcing updates to Mutalyzer and its infrastructure.

If you have a private question or a security related issue to discuss, please use the private address info@mutalyzer.nl.

Open Source

Mutalyzer is Open Source and available under the GNU Affero General Public License. Please contact the authors if you want to discuss custom licensing.

Contributions to Mutalyzer are very welcome! They can be feature requests, bug reports, bug fixes, unit tests, documentation updates, or anything else you may come up with.

Development of Mutalyzer happens on GitHub: github.com/mutalyzer/mutalyzer

If you're interested in running your own Mutalyzer installation, please have a look at our Mutalyzer Ansible role for a completely automated deployment.

Development

Mutalyzer 2.0.34 is designed and developed by Jeroen F.J. Laros, with the following exceptions:

• The LRG parser, as well as the Batch interfaces are written by Gerben R. Stouten.
• The position converter interfaces (web service and WWW) are written by Gerard C.P. Schaafsma.
• Current development and maintenance is done by Martijn Vermaat.
• Automatic extraction of variant descriptions is implemented by Jonathan Vis.

Furthermore we would like to thank the following people for their valuable work on previous versions that acted as a guideline for the development of the current version:

• Ernest van Ophuizen.
• Martin Wildeman.
• Corinne Bareil.
• Gerben R. Stouten.

Specifications are given by Peter E.M. Taschner and Johan T. den Dunnen.

Please mention "Lefter M et al. (2021). Mutalyzer 2: Next Generation HGVS Nomenclature Checker. Bioinformatics, btab051" (direct link) when referring to these pages.

The Description Extractor is described separately in "Vis JK et al. (2015). An efficient algorithm for the extraction of HGVS variant descriptions from sequences. Bioinformatics, 2015 Dec 1;31(23):3751-7" (direct link).

We thank the following organisations for their contribution to the development of Mutalyzer.

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Counters

We keep simple counters for the use of the various Mutalyzer services, broken down by interface.

Service	Interface			Total (all interfaces)
	Website	Webservice	Batch job
Syntax checker	49,917	8,718,354	3,349,058	12,117,329
Name checker	16,299,913	47,267,030	92,637,600	156,204,543
Description extractor	17,978	28,126,276	N/A	28,144,254
Position converter	29,010,364	115,571,271	217,313,609	361,895,244
SNP converter	556,303	3,954,344	32,299,927	36,810,574
Batch jobs	48,138	240,847	N/A	288,985
Total (all services)	45,982,613	203,878,122	345,600,194	595,460,929